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It is considered investigational, which is precisely why medical supervision is essential before considering it

Some clinicians recommend microdosing tirzepatide as a maintenance strategy after achieving target weight

To unpack why the mechanism matters for dosing: NNMT sits at a metabolic crossroads

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It corresponds to the last 15 amino acids of human growth hormone (positions 177-191) with an extra tyrosine added at one end to stabilize the molecule